Antimicrobial Resistance in Infectious Disease & Human Health
Because of the remarkable adaptation capabilities of microbes, many antibiotics and other antimicrobials have been rendered obsolete or far less effective due to the onset of antimicrobial resistance. Challenges within the regulatory and business models surrounding antimicrobials have slowed their development and created not only a need for better antimicrobial stewardship, but also for systems and models that encourage the development of new therapies. Antimicrobial resistance, if left unchecked, could become deadlier than cancer by 2050 (10 million deaths), according to the World Health Organization.
New technologies and discoveries are enabling a better understanding of precision diagnostics and therapies that can help aid in fighting antimicrobial resistance, and new organizations and partnerships are being developed to incentivize the development of new therapies and technologies. While there is a long road ahead to prevent the onset of this potential global crisis, there are opportunities ahead to achieve a healthier future
Additional Resources
- Probiotics and Antibiotics Create a Killer Combination (Infection Control Today)
- Development of Non-Traditional Therapies for Bacterial Infections (U.S. Food & Drug Administration)
- Fixing a ‘market failure’: To develop new antibiotics, upend the incentive structure, experts urge (STAT)
- The antibiotic industry is broken (The Economist)
- Preserve the Effectiveness of Antibiotics with a Global Treaty (Chatham House)
- New Molecular Entity (NME) Systemic Antibiotics Approved by the FDA 1980-2009, but Subsequently Withdrawn or Discontinued (The Center For Disease Dynamics, Economics & Policy)
- Development of Non-Traditional Therapies for Bacterial Infections (U.S. Food & Drug Administration)
- Activity Report 2018 (Global Antibiotic Research & Development Partnership)
- Future Prospects for Neisseria gonorrhoeae Treatment (National Center for Biotechnology Information)
- Chicago startup snares $65M to combat drug-resistant superbugs (Modern Healthcare)
- 'Every antibiotic we count on now will be destroyed': The case for treating antibiotic resistance as a national security problem (Advisory Board)
- Prediction of antibiotic resistance in Escherichia coli from large-scale pan-genome data (PLOS)
- Antibiotic Resistance Threats in the United States, 2013 (Center for Disease Control)
- Probiotics may help battle antibiotic resistance (Medical News Today)
- Development of Non-Traditional Therapies for Bacterial Infections (U.S. Food & Drug Administration)
- New business models for antibiotic innovation (National Center for Biotechnology Information)
- New Business Model for Antibiotics (Office of Health Economics)
- High-quality antibiotics (The Center For Disease Dynamics, Economics & Policy)
- Rapid Diagnostic Testing in Antimicrobial Stewardship (CIDRAP Antimicrobial Stewardship Project)
- Using Machine Learning to Battle Antibiotic Resistance (The Scientist)
- Four stories of antibacterial breakthroughs (Nature)
- Phage therapy’s latest makeover (Nature)
- The IRIDICA BAC BSI Assay: Rapid, Sensitive and Culture-Independent Identification of Bacteria and Candida in Blood (PLOS)
- New “Immunobiotic” Could Treat Antibiotic-Resistant Superbugs (Smithsonian Magazine)
- Medical technologies in the fight against antimicrobial resistance (Health Europa)
- New Business Model For Antibiotics (Global Opportunity Explorer)
- Antimicrobial Resistance: Incentivizing Change towards a Global Solution (Chatham House)
- Understanding the Development Challenges Associated with Emerging Non-Traditional Antibiotics (Duke-Margolis Center for Health Policy)
- Tracking Progress to Address AMR (AMR Industry Alliance)
- The drugs don’t work: what happens after antibiotics? (The Guardian)
- UNDERSTAND – ANTIBIOTIC RESISTANCE | Resistance mechanisms (ReAct)
- Origins and Evolution of Antibiotic Resistance (American Society for Microbiology)
- Antimicrobial Resistance: Tackling a crisis for the health and wealth of nations (Review on Antimicrobial Resistance)
- The Coming Cost of Superbugs: 10 Million Deaths Per Year (Wired)
- Startup Raises $42M for Breakthrough Antibiotic Resistance R&D (R&D Magazine)
- About CDC’s Antibiotic Resistance Lab Network (Center for Disease Control)
- The startups waging war against superbugs (The Spokesman-Review)
- Pharmaceutical companies are backing away from a growing threat that could kill 10 million people a year by 2050 (Business Insider)
- Why Peter Thiel is backing a tiny start-up waging war against the global superbug crisis (CNBC)
- A Startup Takes On Antibiotic Resistance (Fortune)
- Stopping antimicrobial resistance would cost just USD 2 per person a year (Organisation for Economic Co-operation and Development)
- Pharma industry launches call for coalition of countries to pilot new incentives for antibiotic R&D (The International Federation of Pharmaceutical Manufacturers and Associations)
- UK aims to cut antibiotics 15% in 5-year AMR plan (Center for Infectious Disease Research and Policy)
- Creating new antimicrobial drugs will require governments working with industry (Stat)
- What is the difference between antibiotic and antimicrobial resistance? (World Health Organization)
- In the face of slow progress, WHO offers a new tool and sets a target to accelerate action against antimicrobial resistance (World Health Organization)
- Alternatives to Antibiotics: Why and How (National Academy of Medicine)
- Antibiotic / Antimicrobial Resistance: Biggest Threats and Data (Center for Disease Control)
- Technologies to address antimicrobial resistance (Proceedings of the National Academy of Science)
- A ray of hope amid antibiotic gloom (The Pharmaceutical Journal)
- Alternatives to antibiotics-a pipeline portfolio review (Queen's University - Belfast)
- Global Action Plan on Antimicrobial Resistence (World Health Organization)
- Overuse and overprescribing of antibiotics (Center for Infectious Disease Research and Policy)
- Types of Antibiotic-Resistant Infections (NYU Langone Health)
- Bacteriophages to the Rescue: A Possible Approach to Antibiotic Resistance (BioSpace)
- Development of Inhaled Antibacterial Drugs for Cystic Fibrosis and Non-Cystic Fibrosis Bronchiectasis (U.S. Food & Drug Administration)